Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.3
USERS' SCORE
Good
Based on 50 Reviews
8
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Folate (400 mcg as (6S)-5-MTHF [(6S)-5-Methyltetrahydrofolate Glucosamine Salt)
680 mcg DFE‡
170%
Top Medical Research Studies
8
We conducted a case-control study examining how maternal serum folate levels during early to mid-pregnancy might influence the risk of congenital heart disease (CHD) in their children. This research involved participants recruited from one of China's leading cardiac care centers between 2015 and 2018, giving us access to a wealth of valuable data.
Through careful matching of CHD cases and non-CHD controls based on maternal age, we wanted to pinpoint whether variations in folate levels—alongside vitamin B12 and homocysteine levels—had any effect on heart disease in infants. Our findings highlighted a concerning trend: low levels of maternal folate were tied to an increased risk of CHD in offspring. Interestingly, we also discovered that unusually high folate levels were associated with elevated risks.
As we reflected on these results, it's clear that there might be a delicate balance when it comes to folate levels during pregnancy. While ensuring adequate folate is essential, the risk associated with excessive levels prompts further questions. Future studies will be crucial to unpacking these relationships and understanding the mechanisms at play.
Through careful matching of CHD cases and non-CHD controls based on maternal age, we wanted to pinpoint whether variations in folate levels—alongside vitamin B12 and homocysteine levels—had any effect on heart disease in infants. Our findings highlighted a concerning trend: low levels of maternal folate were tied to an increased risk of CHD in offspring. Interestingly, we also discovered that unusually high folate levels were associated with elevated risks.
As we reflected on these results, it's clear that there might be a delicate balance when it comes to folate levels during pregnancy. While ensuring adequate folate is essential, the risk associated with excessive levels prompts further questions. Future studies will be crucial to unpacking these relationships and understanding the mechanisms at play.
Read More
9
We explored the potential benefits of folic acid in treating dangerous heart rhythm problems linked to TANGO2-deficiency disorder (TDD). By creating patient-derived heart cell models, we observed that high doses of folate significantly reduced these arrhythmias. Additionally, clinical studies indicated that taking multivitamins, particularly those rich in B complex, lowered the chance of heart crises in TDD patients. Together, these findings suggest that B vitamins, including folate, could be vital in managing severe heart complications associated with this rare genetic disorder.
Read More
8
We investigated whether folic acid treatment could help lower heart disease risk related to elevated homocysteine levels. The study highlighted that hyperhomocysteinemia is a significant independent risk factor for atherosclerosis, which can contribute to serious cardiovascular events. While folic acid, alongside other B vitamins, effectively reduces homocysteine levels, it does not appear to significantly improve heart disease outcomes on its own. Thus, while folic acid plays a role in managing homocysteine, its impact on preventing heart disease is less clear.
Read More
Most Useful Reviews
9
Reduces homocysteine levels
301 people found this helpful
Fully active folate helped lower my homocysteine level from 10 to 7, which is crucial for reducing heart disease risk. My mother’s level was 15, and now she takes folate with me. If you found this helpful, please like!
Read More
9
Lowers vascular risk
221 people found this helpful
My tests showed elevated homocysteine, which can lead to heart disease. Since switching to Methylfolate, my levels dropped from 14 to 5.8 within two weeks. Consult a doctor for a proper dosage to support heart health.
Read More
9
Beneficial for mothers
23 people found this helpful
This supplement is beneficial for pregnant women and their babies, supporting iron and vitamin B12 levels and combating Alzheimer’s. It is also good for heart health. The small 60-capsule package is easy to swallow, and I highly recommend it for its overall health benefits.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.3
- All Researches
9
Maternal folic acid reduces CHD risk
We explored how maternal folic acid supplementation relates to congenital heart disease (CHD) in children. Through a case-control study involving 595 children with CHD and 605 healthy controls, we found that mothers taking folic acid significantly reduced the risk of CHD and its subtypes. Notably, variations in the MTRR gene among offspring were linked to higher CHD risks, but maternal folic acid appeared to mitigate some of this risk. While results are promising, further research with larger samples is essential to fully understand these findings.
Read More
9
We explored the potential benefits of folic acid in treating dangerous heart rhythm problems linked to TANGO2-deficiency disorder (TDD). By creating patient-derived heart cell models, we observed that high doses of folate significantly reduced these arrhythmias. Additionally, clinical studies indicated that taking multivitamins, particularly those rich in B complex, lowered the chance of heart crises in TDD patients. Together, these findings suggest that B vitamins, including folate, could be vital in managing severe heart complications associated with this rare genetic disorder.
Read More
8
We investigated whether folic acid treatment could help lower heart disease risk related to elevated homocysteine levels. The study highlighted that hyperhomocysteinemia is a significant independent risk factor for atherosclerosis, which can contribute to serious cardiovascular events. While folic acid, alongside other B vitamins, effectively reduces homocysteine levels, it does not appear to significantly improve heart disease outcomes on its own. Thus, while folic acid plays a role in managing homocysteine, its impact on preventing heart disease is less clear.
Read More
8
We explored how folic acid affects patients with coronary heart disease (CHD) and hypertension, particularly considering the MTHFR C677T gene. The study included 540 patients who received either folic acid treatment alongside enalapril or standard care.
While both folic acid and non-folic acid groups showed lower rates of cardiovascular events compared to the control group, the results suggested folic acid may enhance patient outcomes in those with H-type hypertension. Overall, folic acid seems to support better blood pressure management and improves prognosis among high-risk patients, highlighting the importance of genetic screening in treatment.
While both folic acid and non-folic acid groups showed lower rates of cardiovascular events compared to the control group, the results suggested folic acid may enhance patient outcomes in those with H-type hypertension. Overall, folic acid seems to support better blood pressure management and improves prognosis among high-risk patients, highlighting the importance of genetic screening in treatment.
Read More
8
We explored a new silk fibroin and hydroxypropyl cellulose hydrogel designed to improve heart repair after a myocardial infarction by using folic acid-modified extracellular vesicles (EVs). This method aims to overcome the challenge of EV retention in the heart.
Our findings suggest that the hydrogels not only support cell viability but also boost cell migration, contributing to tissue repair by reducing fibrosis and enhancing blood vessel growth in heart tissue. In essence, this innovative approach shows promise for advancing treatments for heart damage.
Our findings suggest that the hydrogels not only support cell viability but also boost cell migration, contributing to tissue repair by reducing fibrosis and enhancing blood vessel growth in heart tissue. In essence, this innovative approach shows promise for advancing treatments for heart damage.
Read More
User Reviews
USERS' SCORE
Good
Based on 50 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Reduces homocysteine levels
301 people found this helpful
Fully active folate helped lower my homocysteine level from 10 to 7, which is crucial for reducing heart disease risk. My mother’s level was 15, and now she takes folate with me. If you found this helpful, please like!
Read More
9
Lowers vascular risk
221 people found this helpful
My tests showed elevated homocysteine, which can lead to heart disease. Since switching to Methylfolate, my levels dropped from 14 to 5.8 within two weeks. Consult a doctor for a proper dosage to support heart health.
Read More
9
Beneficial for mothers
23 people found this helpful
This supplement is beneficial for pregnant women and their babies, supporting iron and vitamin B12 levels and combating Alzheimer’s. It is also good for heart health. The small 60-capsule package is easy to swallow, and I highly recommend it for its overall health benefits.
Read More
9
Homocysteine reduction
18 people found this helpful
Methylfolate is a superb, easily digestible form of vitamin B9. After taking two capsules daily for two months, my homocysteine levels decreased significantly. I would highly recommend it, especially for anyone planning a pregnancy, as it supports fertility and lowers the risk of heart disease.
Read More
9
Lowers heart rate
7 people found this helpful
I am very pleased with this supplement. I’ve been using it for six months and noticed my pulse has dropped to around 65, which is a significant improvement. After struggling with my heart rate for years, I highly recommend this for anyone with similar issues.
Read More
Frequently Asked Questions
9
Lowers vascular risk
221 people found this helpful
My tests showed elevated homocysteine, which can lead to heart disease. Since switching to Methylfolate, my levels dropped from 14 to 5.8 within two weeks. Consult a doctor for a proper dosage to support heart health.
9
Homocysteine reduction
18 people found this helpful
Methylfolate is a superb, easily digestible form of vitamin B9. After taking two capsules daily for two months, my homocysteine levels decreased significantly. I would highly recommend it, especially for anyone planning a pregnancy, as it supports fertility and lowers the risk of heart disease.
9
Anxiety relief
7 people found this helpful
My doctor recommended 5-MTHF to manage my high homocysteine levels linked to heart disease and inflammation. Since taking this for only three days, I have been able to sleep through the night, which has greatly improved my overall wellbeing.
9
Cholesterol management
10 people found this helpful
I chose this product for its adequate dosage and took it alongside omega-3 and vitamin D3 to improve heart function and lower cholesterol. After two months, my cholesterol level decreased to a normal range, which I am very pleased about.
7.5
Supports B12 absorption
6 people found this helpful
This methylfolate is excellent alongside vitamin B12. I found my B12 levels were low, so I began this supplement as they work together. I've been feeling much better and am looking forward to my next test results.
7.5
Reduces cardiovascular risk
5 people found this helpful
I take methylfolate once a year at 400 mcg to keep my homocysteine levels normal and reduce cardiovascular disease risk. It's particularly effective for women planning pregnancy, and the capsules are easy to swallow.
9
Maternal folic acid reduces CHD risk
We explored how maternal folic acid supplementation relates to congenital heart disease (CHD) in children. Through a case-control study involving 595 children with CHD and 605 healthy controls, we found that mothers taking folic acid significantly reduced the risk of CHD and its subtypes. Notably, variations in the MTRR gene among offspring were linked to higher CHD risks, but maternal folic acid appeared to mitigate some of this risk. While results are promising, further research with larger samples is essential to fully understand these findings.
8
We conducted a case-control study examining how maternal serum folate levels during early to mid-pregnancy might influence the risk of congenital heart disease (CHD) in their children. This research involved participants recruited from one of China's leading cardiac care centers between 2015 and 2018, giving us access to a wealth of valuable data.
Through careful matching of CHD cases and non-CHD controls based on maternal age, we wanted to pinpoint whether variations in folate levels—alongside vitamin B12 and homocysteine levels—had any effect on heart disease in infants. Our findings highlighted a concerning trend: low levels of maternal folate were tied to an increased risk of CHD in offspring. Interestingly, we also discovered that unusually high folate levels were associated with elevated risks.
As we reflected on these results, it's clear that there might be a delicate balance when it comes to folate levels during pregnancy. While ensuring adequate folate is essential, the risk associated with excessive levels prompts further questions. Future studies will be crucial to unpacking these relationships and understanding the mechanisms at play.
Through careful matching of CHD cases and non-CHD controls based on maternal age, we wanted to pinpoint whether variations in folate levels—alongside vitamin B12 and homocysteine levels—had any effect on heart disease in infants. Our findings highlighted a concerning trend: low levels of maternal folate were tied to an increased risk of CHD in offspring. Interestingly, we also discovered that unusually high folate levels were associated with elevated risks.
As we reflected on these results, it's clear that there might be a delicate balance when it comes to folate levels during pregnancy. While ensuring adequate folate is essential, the risk associated with excessive levels prompts further questions. Future studies will be crucial to unpacking these relationships and understanding the mechanisms at play.
8
We investigated whether folic acid treatment could help lower heart disease risk related to elevated homocysteine levels. The study highlighted that hyperhomocysteinemia is a significant independent risk factor for atherosclerosis, which can contribute to serious cardiovascular events. While folic acid, alongside other B vitamins, effectively reduces homocysteine levels, it does not appear to significantly improve heart disease outcomes on its own. Thus, while folic acid plays a role in managing homocysteine, its impact on preventing heart disease is less clear.
8
We explored how folic acid affects patients with coronary heart disease (CHD) and hypertension, particularly considering the MTHFR C677T gene. The study included 540 patients who received either folic acid treatment alongside enalapril or standard care.
While both folic acid and non-folic acid groups showed lower rates of cardiovascular events compared to the control group, the results suggested folic acid may enhance patient outcomes in those with H-type hypertension. Overall, folic acid seems to support better blood pressure management and improves prognosis among high-risk patients, highlighting the importance of genetic screening in treatment.
While both folic acid and non-folic acid groups showed lower rates of cardiovascular events compared to the control group, the results suggested folic acid may enhance patient outcomes in those with H-type hypertension. Overall, folic acid seems to support better blood pressure management and improves prognosis among high-risk patients, highlighting the importance of genetic screening in treatment.
References
- Ruan X, Shang W, Lu J, Li Z, Yang J, et al. Maternal multivitamin supplementation mitigates the risk of fetal congenital heart disease associated with high indoor total volatile organic compounds exposure in east china: a case-control study. Environ Health. 2024;23:110. doi:10.1186/s12940-024-01150-7
- Li L, Ou J, Chen Y, Chen Q, Luo M, et al. Association of maternal folic acid supplementation and offspring MTRR gene polymorphism with congenital heart disease: a hospital-based case-control study in Han population. J Health Popul Nutr. 2024;43:220. doi:10.1186/s41043-024-00699-w
- Prasad K. Atherogenic Effect of Homocysteine, a Biomarker of Inflammation and Its Treatment. Int J Angiol. 2024;33:262. doi:10.1055/s-0044-1788280
- Ma L, Zeng L, Wang X. MTHFR C677T gene polymorphism in patients with coronary heart disease and hypertension treated with enalapril and folic acid: implications for prognosis. Cell Mol Biol (Noisy-le-grand). 2024;70:142. doi:10.14715/cmb/2024.70.9.20
- Ruan XR, Sun MT, Wei JH, Luo MJ, Liu HJ, et al. [Maternal gene polymorphisms and their interactions with periconceptional folic acid supplementation in relation to offspring ventricular septal defects]. Zhongguo Dang Dai Er Ke Za Zhi. 2024;26:899. doi:10.7499/j.issn.1008-8830.2403067
- Xu W, Cao Y, Stephens SB, Arredondo MJ, Chen Y, et al. Folate as a potential treatment for lethal ventricular arrhythmias in TANGO2-deficiency disorder. JCI Insight. 2024;9. doi:10.1172/jci.insight.171005
- Hua Y, He Z, Ni Y, Sun L, Wang R, et al. Silk fibroin and hydroxypropyl cellulose composite injectable hydrogel-containing extracellular vesicles for myocardial infarction repair. Biomed Phys Eng Express. 2024;10. doi:10.1088/2057-1976/ad40b2
- Liu L, Zhang X, Geng HR, Qiao YN, Gui YH, et al. High paternal homocysteine causes ventricular septal defects in mouse offspring. iScience. 2024;27:109447. doi:10.1016/j.isci.2024.109447
- Sobot T, Bajic Z, Skrbic R, Uletilovic S, Mandic-Kovacevic N, et al. Effect of folic acid on isoprenaline-induced myocardial injury in rats. Physiol Int. 2024;111:80. doi:10.1556/2060.2023.00291
- Bennett DA, Parish S, Millwood IY, Guo Y, Chen Y, et al. MTHFR and risk of stroke and heart disease in a low-folate population: a prospective study of 156 000 Chinese adults. Int J Epidemiol. 2023;52:1862. doi:10.1093/ije/dyad147
- Chen L, Yang T, Wang T, Sun M, Qin J. Relationships between Maternal Folic Acid Supplementation and Gene Polymorphisms in Patients with Non-Chromosomal Congenital Heart Disease: A Hospital-Based Case-Control Study in China. Nutrients. 2023;15. doi:10.3390/nu15204478
- Ju DT, Huang RS, Tsai BC, Su YC, Chiu PL, et al. Folic Acid and Folinic Acid Protect Hearts of Aging Triple-transgenic Alzheimer's Disease mice via IGF1R/PI3K/AKT and SIRT1/AMPK Pathways. Neurotox Res. 2023;41:648. doi:10.1007/s12640-023-00666-z
- Dkhillon D, Samogulova A, Kolobov B. B Vitamins as Adjunctive Treatment for Chronic Heart Failure. Cardiovasc Hematol Disord Drug Targets. 2023;23:64. doi:10.2174/1871529X23666230719090419
- Webber DM, Li M, MacLeod SL, Tang X, Levy JW, et al. Gene-Folic Acid Interactions and Risk of Conotruncal Heart Defects: Results from the National Birth Defects Prevention Study. Genes (Basel). 2023;14. doi:10.3390/genes14010180
- Qu Y, Liu X, Lin S, Bloom MS, Wang X, et al. Maternal Serum Folate During Pregnancy and Congenital Heart Disease in Offspring. JAMA Netw Open. 2024;7:e2438747. doi:10.1001/jamanetworkopen.2024.38747
